High matrix metalloproteinase-9 expression induces angiogenesis and basement membrane degradation in stroke-prone spontaneously hypertensive rats after cerebral infarction

• DOI: 10.4103/1673-5374.135318
• Publication Date: 2014-06-24T15:17:44Z
• Authors: Huilian Hou; Guanjun Zhang; Hongyan Wang; Huilin Gong; Chunbao Wang; Xuebin Zhang
• Keywords: Microvessel; Stroke

Basement membrane degradation and blood-brain barrier damage appear after cerebral infarction, severely impacting neuronal brain functioning; however, the underlying pathogenetic mechanisms remain poorly understood. In this study, we induced infarction in stroke-prone spontaneously hypertensive rats by intragastric administration of high-sodium water (1.3% NaCl) for 7 consecutive weeks. Immunohistochemical immunofluorescence assays demonstrated that, compared with non-infarcted contralateral hemisphere, on normal sodium intake Wistar-Kyoto rats, matrix metalloproteinase-9 expression, number blood vessels discontinuous collagen IV expression microvessel density were significantly higher, continuous IV-positive was lower infarct border zones given water. Linear correlation analysis showed positively correlated discontinuously IV-labeled infarcts rats. These results suggest that upregulation is associated increased regional angiogenesis IV, major component basal lamina, water-induced focal infarction.