Effects of melatonin on biochemical factors and food and water consumption in diabetic rats

• DOI: 10.4103/2277-9175.139191
• Publication Date: 2014-08-20T12:13:07Z
• Authors: Mousa-Al-Reza Had...; Bahram Bibak; Monavareh Khalili; Ziba Rajaei; Mohammad Soukhtanloo; Parichehr Hayatda...
• Keywords: Polydipsia; Diabetic Neuropathy

Background: Diabetic neuropathy is one of the serious problems due to microvessel vasculopathy in diabetes. It has been reported that hyperglycemia and hypertriglyceridemia are underlying mechanisms inducing progression diabetic neuropathy. The aim present study was investigate effects melatonin on serum glucose lipid levels, as well food consumption water intake streptozotocin-induced rats. Materials Methods: Eighty male Wistar rats were randomly assigned six groups including; normal control group, group 4 experimental received intraperitoneally at doses 2.5, 5, 10, 20 mg/kg end sixth week after verification by means evaluation sciatic nerve conduction velocity (MNCV), for two weeks. Blood body weight, amounts consumption, determined all weeks 0 (before diabetes induction), 3, 6, eighth week. Results: Treatment with reduced significantly (P < 0.001) triglyceride 0.05) 0.001), However, had no significant effect weight animals. Conclusions: could improve several signs diabetes, including hyperglycemia, hypertriglyceridemia, polyphagia, polydipsia. Therefore, may be used an adjunct therapy treatment