Progressive Supranuclear Palsy in India: Past, Present, and Future

• DOI: 10.4103/aian.aian_515_24
• Publication Date: 2024-12-02T16:08:08Z
• Authors: Srinivas Raju; Kuldeep Shetty; Lulup Sahoo; Vijayashankar Par...; Jay M Iyer; Suvorit Bowmick; Soaham Desai; Deepika Joshi; Niraj Kumar; Sahil Mehta; Rukmini Mridula K...; Pettarusp Wadia; Atanu Biswas; Divyani Garg; Pankaj Agarwal; Syam Krishnan; Jacky Ganguly; Heli Shah; Mitesh Chandarana; Hrishikesh Kumar; Rupam Borgohain; VL Ramprasad; Prashanth Lingapp...
• Keywords: Expansive

Abstract Progressive supranuclear palsy (PSP) has emerged as a key area of interest among researchers worldwide, including those in India, who have actively studied the disorder over past several decades. This review meticulously explores extensive range Indian research on PSP up to present and offers insights into both current initiatives potential future directions for managing within region. Historical contributions spanned 80 publications from 1974 2023, encompassing diverse themes clinical phenotyping historical analysis isolated investigative studies therapeutic trials. Traditionally, these been conducted single centers or specific departments, involving broad recruitment numbers. The most frequently encountered phenotype is PSP-Richardson’s syndrome, with patients typically presenting at an average age 64 years, alongside various other subtypes. Recently, there significant shift toward more collaborative models, moving isolated, center-based expansive, multicentric, pan India projects. A prime example this new approach PAn Registry (PAIR-PSP) project, which represents comprehensive effort uniformly examine demographic, clinical, genetic facets across India. Looking ahead, critical need focused unraveling insights, identifying risk factors, developing effective treatment interventions preventive models. Given its vast population, India’s role advancing our understanding tauopathies could be pivotal, work reflects till now.