Tumor necrosis factor-α, CD1A and CD1E genetic polymorphisms in Guillain-Barré syndrome: A study from India

• DOI: 10.4103/aian.aian_834_22
• Publication Date: 2023-03-29T04:15:40Z
• Authors: Rajesh Verma; Rajarshi Chakraborty; Amita Jain; RavindraK Garg; Virendra Atam; HardeepS Malhotra; PraveenK Sharma; Shantanu Prakash; Neeraj Kumar; Shweta Pandey; Ravi Uniyal; Imran Rizvi
• Keywords: SNP

Guillain-Barré Syndrome (GBS) is an acute acquired autoimmune inflammatory disorder of peripheral nerves and roots. The pathogenesis essentially aberrant post-infectious immune response in a genetically susceptible host milieu. Single nucleotide polymorphisms (SNP) genes encoding the mediators like TNF-α, CD1A CD1E can influence their expression level susceptibility clinical course disease GBS.We tried to study single TNF-α CD1 Indian population determine association terms genotype, allele haplotype distribution along with individual subtype, severity outcome.In this case-control study, we investigated polymorphism pattern promoter region (-308 G/A), (-863C/A), using real-time polymerase chain reaction 75 GBS patients analysed comparison age sex-matched healthy controls.The findings revealed that allelic G/A) *A was associated (P value 0.04, Odds Ratio 2.03, 95% Confidence Interval 1.01-4.07). There no found combination other for study. SNPs did not reveal any GBS. subtype analysis statistical significance, except *G AMAN 0.026). haplotypic combinations mutant were significantly severe However, there SNP mortality survival study.TNF-α G/A)*A might confer genetic population. could be considered affect