Hematological parameters of children with sickle cell anemia in steady and crisis states in Zaria, Nigeria

• DOI: 10.4103/atp.atp_22_19
• Publication Date: 2019-07-01
• Authors: Yakubu Saddeeq Ab...; HafsatRufai Ahmad; Jamilu Abdullahi ...
• Keywords: Vaso-occlusive crisis; White blood cell; Outpatient clinic

Background: Sickle cell anemia (SCA) is the most common and severest form of sickle disease. It affects about 3% Nigerian population with a high mortality in children. Hematological parameters are routinely used monitoring SCA patients might vary crisis steady states. Aims Objectives: This study was aimed at comparing hematological state those hemolytic vaso-occlusive Methodology: cross-sectional carried out pediatric outpatient clinic tertiary hospital North West Nigeria. We recruited 170 or state. Five milliliters blood sample collected for full count analysis using Sysmex Xt 2000i automated hematology analyzer. Results: Hemoglobin (Hb) hematocrit (HCT) levels were 8.28 ± 1.64 g/dl 21.8 4.04% while (VOC) 7.81 1.37 22.05 1.37% 4.45 0.12 13.35 0.67, respectively. Total white (WBC) VOC states 14.51 5.21 × 109/l 17.46 5.26 109/l, respectively, had WBC 14.92 5.82 106/l. ANOVA test 0.0001, 0.03, which indicates statistically significant difference between groups. The mean corpuscular volume (MCV), hemoglobin (MCH), concentration (MCHC) 76.67 fl 9.02, 27.18 pg 4.36, 35.17 4.25, state, they 74.88 11.60, 27.24 3.70, 35.49 1.42 and, anemic 76.63 11.74, 26.71 3.78 35.03 1.20, Conclusion: lower during states, although these not significantly different from apart count, Hb, HCT. Therefore, routine should remain an important component management