An Unusual Case of Acquired AGK-BRAF Gene Fusion in Metastatic EGFR-mutant Lung Adenocarcinoma: A Case Report

• DOI: 10.4103/ejcrp.ejcrp-d-24-00023
• Publication Date: 2025-03-10T06:00:27Z
• Authors: Ching-Cheng Chang; Min-Shu Hsieh; Wei-Hsun Hsu

Abstract This case report describes a 60-year-old male patient initially diagnosed with metastatic lung adenocarcinoma harboring an epidermal growth factor receptor (EGFR) exon 21 L858R mutation who subsequently developed rare acquired AGK-BRAF fusion during the course of treatment. highlights complexity managing EGFR-mutant cancer additional genetic alterations, potential role these alterations in treatment resistance, and importance comprehensive genomic profiling guiding personalized strategies.