Diagnostic Value of Procalcitonin in Predicting Bacteremia in Intensive Care Unit

• DOI: 10.4103/ijccm.ijccm_437_17
• Publication Date: 2018-02-19T13:24:41Z
• Authors: Tuna Demirdal; Pinar Sen; Salih Atakan Nemli
• Keywords: Procalcitonin; Bacteremia

IntroductIonSepsis is dysregulated and uncontrolled inflammatory response against infection.The incidence of severe sepsis septic shock has been increasing rapidly in recent years, especially Intensive Care Units (ICUs). [1]Sepsis are also the most common causes death ICU. [2]Early diagnosis rapid initiation appropriate therapy important factors affecting clinical course reducing mortality rate.Therefore, accurate recognition antibiotic treatment lifesaving critically ill patients.Determination causative agent for selection therapy. [3]The isolation microorganisms considered to be gold standard sepsis. [4]However, blood culture positivity can detected approximately 30% bacteremic patients positive cultures may not identified until 48-72 h. [4,5]he sensitivity specificity routine laboratory tests inadequate discriminate between infectious noninfectious conditions.Procalcitonin (PCT) a prehormone calcitonin, it secreted from C cells thyroid gland. [ 6]This hormone released cells, lung, liver, intestines, pancreatic neuroendocrine during inflammation. [7]PCT converted calcitonin completely; however, conversion inhibited by effect cytokines [6]herefore, this molecule negligible serum concentration healthy individuals, found that PCT was elevated, bacterial inflammation, sepsis, organ failure. [8]Hence, more specific than other biomarkers differentiating nonbacterial [9]he aim study evaluate value predicting bacteremia ICU.Background Aims: Several used bacteremia.Procalcitonin inflammation.It aimed diagnostic prognostic Unit (ICU).Materials Methods: A total 156 diagnosed with systemic syndrome, sepsis/septic ICU December 2014 July 2015 were evaluated prospective cohort study.Results: The group consisted 64 (41%) control 92 (59%) nonbacteremic patients.The overall rate 60.3%.Although levels (11.9 ± 21.5 ng/dL) higher (5.9 11.5 ng/dL), difference significant (P = 0.168).The mean Gram-negative bacteria 16.3 27.6 ng/dL, whereas Gram-positive 7.3 10.7 ng/dL 0.145).The significantly nonsurvivors compared survivors (10.1 18.0 vs. 5.7 13.7 ng/dL; P < 0.001).Conclusions: an effective biomarker diagnosing disease severity mortality.There need further well-designed studies confirm critical care.