Iodine status among subclinical and overt hypothyroid patients by urinary iodine assay: A case–control study

• DOI: 10.4103/ijem.ijem_413_16
• Publication Date: 2017-09-15T05:41:27Z
• Authors: Narayan Gautam; Uma Shrestha; KrishnaKumar Agrawal; AmitChandra Jha; Archana Jayan
• Keywords: Subclinical infection; Free thyroxine; Thyroid-stimulating hormone

Objectives: The objective of the study was to assess differences iodine status as measured by urinary excretion (UIE) between cases hypothyroidism and healthy controls. Materials Methods: conducted in with subclinical (n = 58) overt 41) compared age- sex-matched euthyroid controls 52) attending Universal College Medical Sciences Teaching Hospital, Bhairahawa, Nepal. Serum free triiodothyronine (fT3), thyroxine (fT4), thyroid-stimulating hormone (TSH) were estimated competitive ELISA sandwich ELISA, respectively (Diametra, Italy). concentration (UIC) urine samples ammonium persulfate digestion method recommended WHO. Results: A significantly higher median UIC observed among (224.90 μg/l) (281.0 (189.90 (P 0.0001, P 0.001). TSH hypothyroid higher, whereas fT3 lower 0.028, 0.0001), respectively. Similarly, serum fT4 0.015), There positive correlation (r 0.269, negative seen −0.328, 0.0001) −0.145, 0.076). test multiple regression has shown that (β −0.262, 0.012) an independent predictor association UIE cases. Conclusion: Excessive intake found patients assessed concluding it may trigger thyroid hypofunction. Cohort studies generate further evidence should be done explore potential mechanism excess intake.