Evidence of apoptosis in right ventricular dysfunction in rheumatic mitral valve stenosis

• DOI: 10.4103/ijmr.ijmr_686_14
• Publication Date: 2017-03-31T13:12:30Z
• Authors: Shantanu Pande; Prabhat Tewari; Surendra K. Agarwal; Vikas Agarwal; Vinita Agrawal; Megha Chagtoo; Gauranga Majumdar; Satyendra Tewari
• Keywords: Ventricular pressure; Mitral valve stenosis

Right ventricular (RV) dysfunction is one of the causes morbidity and mortality in valvular heart disease. The phenomenon apoptosis, though rare cardiac muscle may contribute to loss its function. Role apoptosis RV patients with rheumatic disease investigated this study.Patients mitral valve stenosis formed two groups based on systolic pressure (RVSP) as RVSP <40 mmHg (group I, n=9) ≥40 II, n=30). Patients having atrial septal defect (ASD) served control III, n=15). Myocardial performance index was assessed for Real-time polymerase chain reaction performed biopsy procured from assess expression pro-apoptotic genes (Bax, cytochrome c, caspase 3 Fas) anti-apoptotic (Bcl-2). Apoptosis confirmed by histopathology terminal deoxynucleotide-transferase-mediated dUTP nick end labelling.Group II had significant compared group I (P=0.05) while (P=0.01) c (P=0.03) were expressed excessively I. When III (control), there no difference function, a highly observed P=0.02, c=0.001 3=0.01). There positive correlation between genes. Nuclear degeneration present conforming (groups II) it absent ASD.Our findings showed evidence set early course even lower RVSP, followed dysfunction; however, regressed.