Role of calcium-sensing receptor, Galectin-3, Cyclin D1, and Ki-67 immunohistochemistry to favor in the diagnosis of parathyroid carcinoma

• DOI: 10.4103/ijpm.ijpm_85_17
• Publication Date: 2018-03-21T13:04:54Z
• Authors: Nuran Sungu; HayriyeTatli Dogan; Aydan Kiliçarslan; Mehmet Kiliç; Sefika Polat; Mehmet Tokaç; Soner Akbaba; Ömer Parlak; Serdar Balci; Betül Ögüt; Bekir Çakir
• Keywords: Parathyroid carcinoma; Parathyroid neoplasm

As histopathological findings of parathyroid carcinoma are not certain, the diagnosis tumors with degenerative changes may be difficult. In these cases, immunohistochemical markers beneficial. We aimed to research acceptability calcium-sensing receptor (CaSR), Galactin-3, Cyclin D1, and Ki-67 as helpful in cases which difficult diagnose.Those who had been diagnosed atypical adenoma between 2010 2015 were reevaluated. İmmunohistochemical applied this cases.About 21 adenoma, 14 10 carcinoma. According results, global loss CaSR staining was seen 50% (5/10) patients while there no those (P = 0,001). Global found only one out adenoma. The expression Galactin-3 positive 40% (4/10) 71.4% (10/14) 14.3% (3/21) 0,002). D1 determined 70% (7/10) carcinoma, 23.8% (5/21) proliferation index above 5% 35,7% (5/14) adenoma.In studies, it has emphasized that used a negative marker study, we have also confirmed is useful determine potential increased malignancy.