Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?

• DOI: 10.4103/jcrt.jcrt_322_17
• Publication Date: 2018-10-30T11:20:25Z
• Authors: Ibrahim Aydogdu; Yusuf Ozlem Ilbey; Ganime Coban; Rahmi Gokhan Ekin; Semih Lutfi Mirap...; Ali Cay; Huriye Senay Kizi...; Zubeyde Yildirim ...; Mesrur Selcuk Silay; Mehmet Bulent Sem...
• Keywords: TBARS; Thiobarbituric acid

We investigate the protective and therapeutic effects of ozone therapy (OT) in radiotherapy (RT)-induced testicular damage.Thirty healthy adult male Wistar rats divided into five groups consisting six animals each as follows: (1) Control (C), (2) RT, (3) OT, (4) OT + (5) RT group. Histopathological findings, Johnsen scores, thiobarbituric acid-reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, peroxidase (GPx) levels were evaluated.RT caused a significant decrease weight score compared to control In addition, TBARS level was significantly higher, whereas GSH, SOD, GPx lower group when Pre postRT increased decreased level. Furthermore, with OT.The present study showed that is radiation-induced damage. may be beneficial patients who underwent RT.