Multiple interferences of serologic studies in an Epstein–Barr virus-related infectious mononucleosis

• DOI: 10.4103/jmedsci.jmedsci_80_19
• Publication Date: 2020-02-21T10:45:37Z
• Authors: Cherng-Lih Perng; Ruei-Yu Su; Li-Ju Ho
• Keywords: Mononucleosis

<br>Epstein–Barr virus (EBV) infection is a common infectious disease in young adults and children. A 4-year-old boy was presented with enlarged tonsils purulent discharge. Sudden airway collapse desaturation were noted, endotracheal tube intubation performed. The laboratory data demonstrated positive results for EBV immunoglobulin M (IgM). Polyclonal B-cell activation that led to cytomegalovirus (CMV) IgM herpes simplex (HSV) also detected by the interference of heterophilic antibodies. low-dose intravenous (IVIG) infusion performed, an IVIG-related false-positive result CMV G (IgG) observed. After aggressive medical care, discharged under stable condition. Herein, we report important features EBV-related mononucleosis harvested multiple interferences. First, antibodies caused due polyclonal resulted HSV IgM. Second, IVIG interpreted IgG. We must be aware interferences could misinterpret our data.<br>