A prospective study on the administration and titration of oxygen therapy in mechanically ventilated patients

• DOI: 10.4103/joacp.joacp_199_24
• Publication Date: 2025-02-22T12:00:13Z
• Authors: Saurabh Chandrakar; Ankit Agarwal; Gaurav Jain; R Udhayachandhar; Davis Cherian; Nupur B. Patel
• Keywords: Oxygen therapy

Abstract Background and Aims: Medical oxygen (O 2 ) is a lifesaving therapy in the intensive care unit (ICU). However, overzealous use poorly defined O targets ICU patients can increase risk of hyperoxemia. We aimed to assess administration titration requiring invasive mechanical ventilation (IMV) support. Material Methods: In this prospective observational study, all adult IMV for more than 24 hours were included over 1 year (December 2020–November 2021). Patients who refused give consent or required support less hours, did not have arterial blood gas data, at imminent death, extracorporeal membrane oxygenation hyperoxemia excluded. calculated incidence (SpO > 98%), physicians’ response hyperoxemia, factors associated with Multivariable logistic regression (MLR) analysis was done Results: Among 400 recruited 4631 observations, 211 1669 observations had 398 decreased. Physicians reluctant decrease when observed lower inspired (χ = 182.1, P value < 0.001). On MLR analysis, duration IMV, minute ventilation, partial pressure statistically significantly Conclusions: Hyperoxemia approximately one-third noted mechanically ventilated patients. encountered oxygen.