Association between intravenous acetaminophen and reduction in intraoperative opioid consumption during transsphenoidal surgery for pituitary tumors

• DOI: 10.4103/joacp.joacp_276_17
• Publication Date: 2019-12-03T08:06:53Z
• Authors: JuanP Cata; Upasana Banerjee; Katherine Hagan; Shreyas Bhavsar; Roxana Grasu; Anh Dang; IanE McCutcheon; Miguel Suarez; Vijaya Gottumukkala
• Keywords: Acetaminophen; Transsphenoidal surgery

Pain during and after transsphenoidal surgeries originates from stimulation of branches the trigeminal cranial nerve that supply inner aspect nose cavity dura mater. Thereby, patients undergoing surgery may require moderate-to-large amounts analgesics including opioids. Intravenous acetaminophen provides analgesia reduces opioid consumption for a wide variety surgeries. We hypothesized use intravenous is associated with reduction in intraoperative significant surgery.This retrospective study included 413 who underwent pituitary adenomas. The primary outcome this was consumption. Secondary outcomes pain intensity, Richmond Agitation Sedation Scale scores, nausea vomiting upon arrival to postoperative anesthesia care unit. Patients were divided into two groups based on use. A prospensity score matching analysis used balance important variables between treatment. Regression models fitted covariates. P < 0.05 considered statistically significant.After matching, 126 each group required significantly less amount (a decrease by 14.9%) opioids than those non-acetaminophen group. Postoperative pain, vomiting, sedation scores not different received did not.Intravenous surgery.