Radioprotective effect of hesperidin on reducing oxidative stress in the lens tissue of rats

• DOI: 10.4103/jphi.jphi_60_17
• Publication Date: 2017-10-17T09:12:42Z
• Authors: AliShabestani Mon...; Navid Karimi; GholamHassan Haddadi; Abbas Soleymani; Erfan Mohammadi; Karimollah Hajian...; Sajad Borzoueisileh
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Original Research Article; 3. Good health

Introduction: Oxidative stress is a common factor in cataract. Considering the antioxidant properties of hesperidin as flavanone glycoside from flavonoid family with radioprotective effect, this study aimed to determine protective effect on reducing oxidative eye lens tissue mature rats caused by gamma irradiation. Materials and Methods: A total 48 adult were randomly divided into six groups, namely, control, Dimethyl sulfoxide (DMSO), hesperidin, radiation, radiation + DMSO hesperidin. 15 Gy irradiation was carried out using Cobalt-60 teletherapy instrument source-to-surface distance 80 cm at dose rate 98.5 cGy/min. 2 days following irradiation, we removed rats' lenses analyzed them effects Results: The comparison control intervention groups after showed that malondialdehyde (MDA) level significantly higher than group. Furthermore, significant difference between observed. glutathione (GSH) lower compared Nonetheless, elevation GSH group seen. Conclusions: Radiation exposure reduced enhanced MDA levels tissue. However, modulated consumption. These results show antioxidative demonstrated complications such cataract can be through stress.