Evaluation of Serum Adipolin Level as a Potential Marker of Metabolic and Hormonal Changes in Patients with Overt and Subclinical Hypothyroidism

• DOI: 10.4103/mjbl.mjbl_294_24
• Publication Date: 2025-03-31T00:24:47Z
• Authors: Ahmed Salaam Abood; Hanaa Addai Ali
• Keywords: Subclinical infection

Abstract Background: Adipokines are a group of cell signaling proteins produced by adipose tissue. These influence appetite, obesity, and insulin sensitivity, may interact with thyroid hormones. However, the exact relationship between hormones adipokines remains unclear. Objectives: The aim this study was to evaluate compare serum levels adipolin in healthy individuals hypothyroidism patients, including subclinical (SCH) overt (OH). Materials Methods: study’s case–control design involved 90 participants, ranging age from 18 55 years Three groups were created: one consisted 30 who had SCH, OH, remaining comprised control group. Anthropometric characteristics that assessed recorded for every individual age, gender, height, weight, body mass index, hormonal characteristics. Results: People considerably lower than those normal function ( P < 0.001). Moreover, there negative correlation r = 0.667) thyroid-stimulating hormone levels. T4 positively correlated −0.214, receiver operating characteristic curve cutoff area under (AUC) 0.983, value ≤18.7 SCH group, sensitivity 86.7%, specificity 100%, 0.001. For OH ≤14.43, an AUC 1.000, <0.001. Conclusion: results imply blood levels, especially effective biomarker diagnosing monitoring hypothyroidism. exclusion criteria confirmed neither further medication use nor systemic problems impacted outcomes.