Influence of Systolic Blood Pressure on Outcomes in Nigerians with Peripartum Cardiomyopathy

• DOI: 10.4103/njcp.njcp_2005_21
• Publication Date: 2023-05-15T09:07:49Z
• Authors: H Sa′idu; SA Balarabe; NA Ishaq; UG Adamu; IY Mohammed; I Oboirien; EM Umuerri; AC Mankwe; VY Shidali; P Njoku; S Dodiyi-Manuel; T Olunuga; V Josephs; AC Mbakwem; H Okolie; MA Talle; MS Isa; RA Adebayo; J Tukur; SA Isezuo; H Umar; MN Shehu; OS Ogah; KM Karaye
• Keywords: Peripartum Cardiomyopathy; Nigerians; Systole

Background: The relationship between blood pressure (BP) trajectories and outcomes in patients with peripartum cardiomyopathy (PPCM) is not clear. Aim: study aimed to assess the clinical features (all-cause mortality unrecovered left ventricular [LV] systolic function) of PPCM grouped according their baseline BP (SBP). Patients Methods: presenting 14 tertiary hospitals Nigeria were consecutively recruited June 2017 March 2018 then followed up till 2019. SBP at first presentation was used categorize into seven groups: <90, 90–99, 100–109, 110–119, 120–129, 130–139, ≥140 mmHg. Unrecovered LV function defined as echocardiographic ejection fraction (LVEF) below 55% last profiling. Results: Two hundred twenty-seven for a median 18 months. Of these, 4.0% had <90 mmHg, 16.3% 90–99 24.7% 100–109 110–119 18.5% 120–129 7.5% 130–139 4.4% mmHg presentation. highest frequency all-cause recorded among ≤90 (30.8%) by those (20.5%) ( P = 0.076), while did differ significantly groups 0.659). In Cox proportional regression model mortality, hazard ratio (HR) 4.00 (95% confidence interval [CI] 1.49–10.78, 0.006), LVEF an HR 0.94 CI 0.91–0.98, 0.003, B 0.06%), use angiotensin-converting enzyme or angiotensin receptor and/or β-receptor blockers 1.71 0.93–3.16, 0.085). However, associated recovery. Conclusion: our cohort patients, one-fifth hypotensive four-fold higher risk during follow-up