Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

• DOI: 10.4103/nrr.nrr-d-23-01706
• Publication Date: 2024-11-29T07:03:01Z
• Authors: Yan Li; Peng Hao; Hongmei Duan; Fei Hao; Wen Zhao; Yudan Gao; Zhaoyang Yang; Kwok-Fai So; Xiaoguang Li
• Keywords: cortical remodeling; functional recovery; proliferation; adult endogenous neurogenesis; motor cortex injury; newborn neurons; Neurology. Diseases of the nervous system; basic fibroblast growth factor-hyaluronic acid collagen gel; migration; RC346-429; neural circuits; neural stem cells

JOURNAL/nrgr/04.03/01300535-202510000-00024/figure1/v/2024-11-26T163120Z/r/image-tiff The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that central nervous system can be repaired and regenerated after injury. However, whether it is possible to stimulate neurogenesis reconstruct cortical layers II VI non-neurogenic regions, such as cortex, remains unknown. In this study, we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into motor cortex immediately following traumatic Our findings reveal effectively stimulated proliferation migration cells, well their differentiation mature functionally integrated neurons. Importantly, these new neurons reconstructed architecture VI, existing circuitry, ultimately led improved function. These offer novel insight potential clinical treatments for cerebral injuries.