Understanding the link between type 2 diabetes mellitus and Parkinson’s disease: role of brain insulin resistance

• DOI: 10.4103/nrr.nrr-d-23-01910
• Publication Date: 2024-04-05T08:04:26Z
• Authors: Theodora Ntetsika; Sergiu-Bogdan Cat...; Ioanna Markaki
• Keywords: 0303 health sciences; diabetes type 2; parkinson’s disease; glp-1 signaling; brain insulin resistance; neurodegeneration; targeted therapy; 03 medical and health sciences; insulin resistance; glp-1 receptor agonists; Neurology. Diseases of the nervous system; RC346-429; insulin signaling; brain insulin signaling

Type 2 diabetes mellitus and Parkinson’s disease are chronic diseases linked to a growing pandemic that affects older adults causes significant socio-economic burden. Epidemiological data supporting close relationship between these two aging-related have resulted in the investigation of shared pathophysiological molecular mechanisms. Impaired insulin signaling brain has gained increasing attention during last decade been suggested contribute development through dysregulation several pathological processes. The contribution type resistance neurodegeneration disease, with emphasis on resistance, is extensively discussed this article new therapeutic strategies targeting link presented reviewed.