Animal model evaluation of a novel renal denervation system for future laparoscopic treatment of resistant hypertension

• DOI: 10.4111/icu.2020.61.1.107
• Publication Date: 2020-01-07T02:03:38Z
• Authors: Won Hoon Song; Jinhwan Baik; Sunchoel Yang; Eue-Keun Choi; Sung-Min Park; Chang Wook Jeong
• Keywords: Animal model

Although percutaneous catheter-based ablation of renal sympathetic nerve fibers has been used in the treatment patients with resistant hypertension, a recent phase III study did not confirm its efficacy. In this study, we developed novel laparoscopic denervation system and evaluated safety initial feasibility using an animal model.A surgical instrument that uses smart algorithm temperature-monitoring feedback was developed. We 4 male pigs (6 weeks old, weighing approximately 45 kg each) to evaluate efficacy system. performed immunohistochemical staining analysis after various tip temperatures over durations through open approach.When temperature outer wall artery maintained at 90℃ for 180 seconds, completely denervated without damaging inner layer, as Masson's trichrome staining. When ranged from 70℃ duration 90 420 partial or complete significant vessel injury confirmed anti- growth-associated protein 43 anti-S100 staining.This A safe effective protocol constant tissue within seconds. However, further developments are necessary before clinical use.