MUC1 as a Putative Prognostic Marker for Prostate Cancer

• DOI: 10.4137/bmi.s666
• Publication Date: 2017-11-08T10:05:31Z
• Authors: Rona J Strawbridge; Monica Nistér; Kerstin Brismar; Henrik Grönberg; Chunde Li
• Keywords: MUC1

MUC1 is expressed on the apical surface of glandular epithelium. With functions including protection, adhesion and signaling, has been implicated in prostate cancer. There are many splice variants, best characterized which MUC1/1 MUC1/2 determined by a SNP (rs4072037, 3506G>A). Blood DNA from general population, BPH, sporadic hereditary cancer subjects were genotyped for rs4072037 SNP. G allele frequencies significantly reduced (15%) compared to BPH or samples (27%, 39% 26% respectively). In addition, was lost 3 8 heterozygous tumor matched blood DNA. Bioinformatics analysis protein sequences provides insight into differences between variants may be functionally relevant. The literature indicates discrepancies immunohistochemical studies, possibly due variety epitopes targeting diverse regions molecule. contradictory findings cell lines highlight problem associated with inadequate experimental systems. This first report genetic prostatic tissue. finding important as proof principle, given that association studies focus rather than As yet, potential functional paid little attention. Antibodies discriminate standardization methods would help clarify whether there role prognostic marker.