Paraganglioma of Prostatic Origin

• DOI: 10.4137/ccrep.s9742
• Publication Date: 2012-05-21T21:29:05Z
• Authors: B. Padilla-Fernández; P. Antúnez-Plaza; M.F. Lorenzo-Gómez; M. Rodríguez-Gonz...; A. Martín-Rodríguez; J.M. Silva-Abuín
• Keywords: Terazosin; Rectal examination

Paragangliomas are usually benign tumors arising from chromaffin cells located outside the adrenal gland. Prostatic paraganglioma is an unusual entity in adult patients, with only 10 cases reported medical literature.A 34-year-old male a history of chronic prostatitis consulted for perineal pain. On digital rectal examination prostate was enlarged and firm, without nodules. The PSA level 0.8 ng/mL catecholamines urine were elevated. ultrasound retrovesical 9 cm mass undetermined origin measuring present. A PET-CT scan showed pelvic lesion moderate increase glucidic metabolism localized area prostate. biopsy revealed neuroendocrine tumor, possibly prostatic paraganglioma. body scintigraphy MIBG I-123 ruled out presence metastases or multifocal tumor. radical prostatectomy excision performed under adrenergic blockade. One year after surgery patient asymptomatic disease free.Prostatic rare, which should be considered differential diagnosis young males. Its based on determination catecholamine blood 24-hour imaging studies principally I-123. Diagnostic confirmation by histopathological study. treatment consists resection blockade volume expansion. Given limited number reported, it difficult to establish prognostic factors. Malignancy defined clinical criteria, requires life long follow-up.