Intensity-Modulated Radiotherapy versus Three-Dimensional Conformal Radiotherapy in Definitive Chemoradiotherapy for Cervical Esophageal Squamous Cell Carcinoma: Comparison of Survival Outcomes and Toxicities

• DOI: 10.4143/crt.2018.624
• Publication Date: 2019-04-30T02:52:14Z
• Authors: Nai-Bin Chen; Bo Qiu; Jun Zhang; Meng-Yun Qiang; Yu-Jia Zhu; Bin Wang; Jin-Yu Guo; Ling-Zhi Cai; Shao-Min Huang; Meng-Zhong Liu; Qun Li; Yong-Hong Hu; Qi-Wen Li; Hui Liu
• Keywords: Esophagitis; Chemoradiotherapy; Pneumonitis

The purpose of this study was to compare the survival and toxicities in cervical esophageal squamous cell carcinoma (CESCC) treated by concurrent chemoradiothrapy with either three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated (IMRT) techniques.A total 112 consecutive CESCC patients were retrospectively reviewed. 3D-CRT IMRT groups had been analyzed propensity score matching method, sex, age, Karnofsky performance status, induction chemotherapy, tumor stage well matched. Kaplan-Meier method Cox proportional hazards model used for overall (OS) progression-free (PFS). Toxicities compared between two Fisher exact test.With a median follow-up time 34.9 months, 3-year OS (p=0.927) PFS (p=0.859) rate 49.6% 45.8% group, 54.4% 42.8% group. rates grade ≥ 3 esophagitis, 2 pneumonitis, stricture, hemorrhage comparable groups, while tracheostomy dependence much higher group than (14.3% vs.1.8%, p=0.032). Radiotherapy technique (hazard ratio [HR], 0.09; 95% confidence interval [CI], 0.01 0.79) pretreatment hoarseness (HR, 0.12; CI 0.02 0.70) independently prognostic dependence.No benefits observed comparing versus patients. fraction dose escalation considered be associated risk dependence. Radiation beyond 60 Gy should taken into account carefully when using hypofractionated regimen.