Protective effect of nebivolol on gentamicin-induced nephrotoxicity in rats

• DOI: 10.4149/bll_2018_128
• Publication Date: 2018-11-29T12:05:45Z
• Authors: M. Dursun; S. Sahin; H. Besiroglu; A. Otunctemur; E. Ozbek; S. S. Cakir; M. Cekmen; A. Somay
• Keywords: Nephrotoxicity; Malondialdehyde; Nebivolol

OBJECTIVE: Nephrotoxicity is a major complication of gentamicin (GEN), which widely used in the treatment severe Gram-negative infections.As we know, with nebivolol has been shown to decrease renal fi brosis and glomerular injury as well improve endothelial dysfunction.Therefore, evaluated potential protective effect (NBV) against GEN-induced nephrotoxicity rats.MATERIAL AND METHOD: Twenty-four rats were randomly divided into four groups: control group (Group 1); intraperitoneally injected GEN (100 mg/kg/day; Group 2); treated plus distilled water 3); NBV (10 4).After 15 days, sacrifi ced, their kidneys taken, blood analysis performed.Tubular necrosis interstitial scores determined histopathologically part kidneys; nitric oxide (NO), malondialdehyde (MDA), reduced glutathione (GSH) levels other kidneys.RESULTS: The GSH tissue only GEN-treated signifi cantly lower than those group, administration increased level GSH.The that was given had MDA NO kidney cortex alone.Despite presence mild tubular degeneration, GEN+NBV showed less necrosis, glomeruli maintained better morphology compared group.CONCLUSION: exerts antioxidant, anti-infl ammatory antifi brotic effects on damage by reducing oxidative stress rat model (Tab.3, Fig. 2, Ref. 68).