The hypothesis of the main role of H2S in coupled sulphide-nitroso signalling pathway

• DOI: 10.4149/gpb_2010_04_402
• Publication Date: 2010-12-03T11:03:05Z
• Authors: A. Bertova; S. Cacanyiova; F. Kristek; O. Krizanova; K. Ondrias; Z. Tomaskova
• Keywords: Nitroso Compounds; Nitroso

As a part of the nitroso signalling pathway, nitroso-compounds serve as stores and carriers NO; sulphide bound sulfane-sulphur compounds H 2 S.Here we hypothesise coupled sulphide-nitroso in which S plays main role.H releases NO from endogenous S-nitroso-compounds nitrosocysteine, nitroso-acetylcysteine nitroso-albumin.Relaxation noradrenaline-precontracted aortic rings by is also enhanced presence nitroso-albumin, may implicate involvement pathway.Pretreatment albumin, cysteine, N-acetylcysteine lipids with results binding sulphur to these creating thus new-modified that release directly and/or through released S, suggests pathway participation.This hypothesis supported observation pretreatment significantly relaxation induced nitroso-glutathione absence S. We assume or indirectly S-induced sulphur-bound represents signalling, explain some numerous biological effects are shared NO.