HPV status and its genomic integration affect survival of patients with cervical cancer

• DOI: 10.4149/neo_2018_170414n277
• Publication Date: 2018-05-17T05:04:16Z
• Authors: M. IBRAGIMOVA; M. TSYGANOV; O. SHPILEVA; O. CHURUKSAEVA; V. BYCHKOV; L. KOLOMIETS; N. LITVIAKOV
• Keywords: Human papillomavirus 16; Virus Integration; Papillomavirus Infections; Uterine Cervical Neoplasms; Genomics; Disease-Free Survival; 3. Good health; Survival Rate; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Neoplasm Recurrence, Local

To evaluate the relapse-free and overall survival of HPV-positive patients with regard to the physical status of type 16 HPV and of HPV-negative patients with primary CC. As a main result of the study the predictive value of the physical status of type 16 HPV was determined for relapse-free and overall survival of patients with CC. Episomal form of the virus is a favorable predictive factor. Integrated form of the virus is a severely unfavorable predictive factor and survival of such patients is significantly lower, than for HPV- patients and patients with mixed form of the virus. The results of the research are data on survival of patients with CC depending on the physical status of the virus (for HPV+ patients) and of patients with HPV-negative cancer.