miR-1246 shuttling from fibroblasts promotes colorectal cancer cell migration

• DOI: 10.4149/neo_2020_200924n1018
• Publication Date: 2020-11-24T10:25:34Z
• Authors: Guifan Si; Suyun Li; Qi Zheng; Shiguo Zhu; Chunxian Zhou
• Keywords: Cancer-Associated Fibroblasts

Cancer-associated fibroblasts (CAFs) are the major constituents of tumor microenvironment and promote cancer development via tumor-stromal interactions. The alteration microRNA (miRNA) expression in can induce phenotype conversion between normal CAFs certain types. However, mechanisms underlying colorectal (CRC) largely unknown. Our study focuses on role miR-1246 fibroblasts-CRC cells interaction. In this study, CCD-18Co were cultured conditioned medium (CM) derived from CRC to obtain CAF phenotype. We found that was upregulated CAF-like compared with fibroblasts. secreted by could be utilized neighboring for reprogramming. On other hand, following secretion fibroblasts, delivered into promoted cell migration activation Wnt/β-catenin signaling cells. Furthermore, high tissues negatively associated disease-free survival (DFS) patients. Taken together, our results reveal shuttle This also indicates targeting or blocking its transport might represent a novel therapeutic approach treatment.