The impact of continuous multicolumn chromatography on biomanufacturing efficiency

• DOI: 10.4155/pbp.13.46
• Publication Date: 2013-09-30T11:23:13Z
• Authors: Marc Bisschops; Mark Brower
• Keywords: Biomanufacturing

Over the past few years, capacity bottleneck in biomanufacturing has shifted from upstream process to purification process. In particular, capture chromatography steps have become a limiting factor facility throughput. This is direct result of discrepancy between expression levels, which increased by ten, and biochromatography media, at best doubled. Continuous countercurrent multicolumn promising approach deal with bottleneck, particularly if designed single-use format. BioSMB™ technology disposable bioprocess that allows standard steps, such as Protein A capture, be executed much less installed chromatographic media using an economically favorable, option where none previously been available. Various case studies demonstrated advantages this for various separations. I...