Adult human mesenchymal cells proliferate and migrate in response to chemokines expressed in demyelination

• DOI: 10.4161/cam.4.2.11404
• Publication Date: 2010-06-25T16:08:27Z
• Authors: Claire M. Rice; Neil J. Scolding
• Keywords: Adult; 0303 health sciences; Mesenchymal Stem Cells; Chemokine CXCL12; 3. Good health; Chemokine CXCL10; 03 medical and health sciences; Cell Movement; Cell Adhesion; Humans; Chemokines; Chemokine CCL5; Cells, Cultured; Chemokine CCL2; Cell Proliferation; Chemokine CCL3; Demyelinating Diseases

Systemic delivery of multipotent mesenchymal stem cells (MSC) may be of benefit in the treatment of neurological diseases, including multiple sclerosis (MS). Certainly, animal studies have demonstrated functional benefits following MSC transplantation, although the mechanisms by which MSCs migrate to lesions and stimulate repair remain unknown. Chemokines stimulate migration in other settings. In this study, we systematically explore the migratory and proliferative responses of human MSCs (hMSC) to chemokines expressed in MS lesions. We demonstrate that these chemokines trigger hMSC migration. In addition, we show that RANTES and IP-10 promote hMSC proliferation.