Selective targeting of histone methylation

• DOI: 10.4161/cc.10.3.14705
• Publication Date: 2011-02-03T21:30:30Z
• Authors: Abul BMMK Islam; William F. Richter; Nuria Lopez-Bigas; Elizaveta V. Bene...
• Keywords: Histone Methylation; Demethylase; Epigenomics; Histone code; Histone-modifying enzymes

Histones are post-translationally modified by multiple histone-modifying enzymes, which in turn influences gene expression. Much of the work field to date has focused on genetic, biochemical and structural characterization these enzymes. The most recent genome-wide methods provide insights into specific recruitment enzymes vivo and, therefore, onto mechanisms establishing a differential expression pattern. Here we focus involved placement two contrasting histone marks, H3 lysine 4 (H3K4) methylation 27 (H3K27) methylation. We describe distribution their binding sites show that different proteins can be coordinated, opposed, or alternating. Specifically, genomic H3K4 demethylase KDM5A become accessible its homolog KDM5B cells with lowered level. currently available data H3K4/H3K27 modifying suggests formed protein complexes targeted sequential temporal manner, but additional, still unknown, interactions contribute targeting specificity.