The fruit ofAcanthopanax senticosus Harmsimproves arterial stiffness and blood pressure: a randomized, placebo-controlled trial

• DOI: 10.4162/nrp.2020.14.4.322
• Publication Date: 2020-07-28T08:00:51Z
• Authors: Eunkyoung Oh; Youjin Kim; Soo-yeon Park; Yeni Lim; Ji-yoon Shin; Ji Yeon Kim; Ji-Hyun Kim; Moo-Yong Rhee; Oran Kwon
• Keywords: Endothelial Dysfunction; Lipid Profile

Arterial stiffness and endothelial dysfunction are 2 of the independent predictors for cardiovascular disease, while Acanthopanax senticosus Harms (ASH) is a traditional medicinal plant that can improve health. This study aimed to investigate efficacy fruit ASH on vascular function in apparently healthy subjects.A 12-week, randomized, double-blind, placebo-controlled design, consisting adults with at least following 3 conditions: borderline high blood pressure (BP; 120 mmHg ≤ systolic BP 160 or 80 diastolic 100 mmHg), smoking (≥10 cigarettes/day), lipid levels (220 total cholesterol 240, 130 low density lipoprotein 165, 150 triglyceride 220 mg/dL). Randomly assigned 76 subjects who received placebo doses (low, 500 mg/day; high, 1,000 mg/day) completed intervention. Brachial-ankle pulse wave velocity (baPWV), flow-mediated dilation, carotid intima-media thickness, were measured both baseline 12-week Endothelial nitric oxide synthase (eNOS) phosphorylation was assessed by western blotting.Compared group, low-dose group showed more significant changes after intervention period terms (0.1 vs. -7.7 mmHg; P = 0.044), baPWV (31.3 -98.7 cm/s; 0.007), ratio phospho-eNOS/eNOS (0.8 1.22; 0.037).These results suggest extract mg/day has potential arterial via eNOS activation tendency having elevated parameters.Clinical Research Information Service Identifier: KCT0001072.