Early Cardiac Dysfunction in Biopsy-proven Nonalcoholic Fatty Liver Disease

• DOI: 10.4166/kjg.2021.040
• Publication Date: 2021-09-27T01:28:59Z
• Authors: Peter C. Johnson; Anthony A. Cochet; Rosco S. Gore; Stephen A. Harrison; John P. Magulick; James K. Aden; Angelo H. Paredes
• Keywords: Subclinical infection

Nonalcoholic fatty liver disease (NAFLD) encompasses a range of diseases from nonalcoholic (NAFL) to steatohepatitis (NASH) and has been linked cardiovascular sub-clinical cardiac remodeling. This paper presents retrospective study biopsy-proven NAFL NASH examine the differences in subclinical remodeling.Patients were recruited an institutional repository patients with liver-biopsy-confirmed NAFLD. Patients transthoracic echocardiogram (TTE) within 12 months biopsy included. The parameters diastolic dysfunction reviewed for between as well stages grades NASH.Thirty-three included study, 17 16 NASH. more likely have lower platelets, higher AST, ALT, rates type 2 diabetes mellitus, coronary artery disease, hypertension than patients. E/e' ratio on was significantly compared NAFL, advanced-stage early stage, high-grade low-grade. also without mellitus. presence trended toward significance. other markers similar. Logistic regression revealed statistical association NASH.NASH had evidence there trend towards significant dysfunction. should be closely monitored signs symptoms