Intestinal Organoid as a Research Platform for the Virus-host Interaction

• DOI: 10.4167/jbv.2023.53.1.051
• Publication Date: 2023-07-11T05:06:26Z
• Authors: Jieun Lee; Subin Lee; Hyungjun Jeon; Garyung Kim; Seyoung Kim; Jihoon Kim
• Keywords: Organoid; Tissue tropism; Viral life cycle

Viral pathogens utilize various human organs for infection, and the gut is one of primary entry sites viral pathogen. The epithelium tightly maintained since multiple harmful substances, including pathogens, attack it. outbreak new viruses or strains often poses a massive threat to life, so we need understand how they develop prevent them by inventing therapeutic approaches, drugs vaccines. Therefore, biology society always eager invent better way investigate infection mechanism, life cycle, drug response, etc. advances research platforms were critical bottlenecks researchers. recent development organoid culture system widely opened opportunities diseases related pathogens. In particular, was quickly applied severe acute respiratory syndrome coronavirus 2 research, providing information about virus potential therapeutics such as cellular tropism, crucial genes involved in replication infection. This review provides comprehensive summary intestinal systems pathogen research.