Juvenile Obesity Aggravates Disease Severity in a Rat Model of Atopic Dermatitis

• DOI: 10.4168/aair.2015.7.1.69
• Publication Date: 2014-12-19T07:01:58Z
• Authors: Keun-Yeong Jeong; Jaehee Lee; Chengjin Li; Taeho Han; Sat-Byol Lee; Hyunkyoung Lee; Seung Keun Back; Heung Sik Na
• Keywords: 0301 basic medicine; 2. Zero hunger; 03 medical and health sciences; Original Article; 3. Good health

There is increasing epidemiological evidence of an association between childhood obesity and atopic dermatitis, but little known about the underlying mechanism(s). In present study, we used a rat model dermatitis to assess whether juvenile obesity, induced by reduction litter size, aggravated signs and, if so, this aggravation was associated with changes in plasma concentration adipokines, such as leptin adiponectin. Dermatitis neonatal capsaicin treatment. Body weight, score, serum IgE, skin nerve growth factor (NGF), adiponectin, cytokine mRNA expression lesion were compared small (SL, 5 pups) large litters (LL, 15 pups). The body weight rats up 6 weeks age significantly heavier SL group, those LL group. group showed more robust development higher levels IgE NGF than Additionally, demonstrated pro-inflammatory lower adiponectin These results suggest causal link decrease immunological tolerance, dermatitis.