Delayed-Onset Anaphylaxis Caused by IgE Response to Influenza Vaccination

• DOI: 10.4168/aair.2020.12.2.359
• Publication Date: 2020-01-30T00:06:54Z
• Authors: Min Jung Kim; Doo Hee Shim; Hye-Ran Cha; Cheong Bi Kim; Soo Yeon Kim; Jeon Han Park; Myung Hyun Sohn; Jae Myun Lee; Kyung Won Kim
• Keywords: 610; delayed hypersensitivity; vaccines; vaccination; Brief Communication; immunoglobulin E; 3. Good health; 618; 03 medical and health sciences; 0302 clinical medicine; influenza; Anaphylaxis; drug hypersensitivity

Influenza vaccine-associated anaphylaxis is a very rare allergic reaction to vaccines, but the most concerning and life-threatening adverse reaction. Although safety of influenza vaccines has been well documented, occasional cases in vaccinated patients have reported. In this study, we analyzed immunoglobulin E (IgE) response whole pediatric case delayed-onset after vaccination. The patient showed elevated specific IgE levels against especially with split virion from egg-based manufacturing process. Specific decreased over. We evaluated causal relationship between vaccine event by enzyme-linked immunosorbent assay. Delayed-onset vaccination can occur children without predisposing diseases. addition, results suggested that formulation production system could affect probability severe vaccines.