Diagnostic Decision Points of Specific Immunoglobulin E Concentrations for Seafood Allergies in Korean Children: A Nationwide Multicenter Study

• DOI: 10.4168/aair.2025.17.1.127
• Publication Date: 2025-01-23T00:07:13Z
• Authors: Minji Kim; Ji Young Lee; Sooyoung Lee; Kyunguk Jeong; Meeyong Shin; Tae Won Song; Minyoung Jung; Jeong Hee Kim; Gwang Cheon Jang; You Hoon Jeon; Taek Ki Min; Yong Ju Lee; Min Jung Kim; Yoonha Hwang; Young Min Ahn; Sukyung Kim; Kangmo Ahn; Jihyun Kim

Shellfish and fish are common causes of food allergy (FA) in Asia, with significant prevalence rates reported across various countries. This study aimed to identify the diagnostic decision points (DDPs) for shrimp, crab, cod allergies Korean children. We enrolled participants aged 18 years or younger suspected through a retrospective review medical records from nationwide 14-center between January 2018 March 2022. FA was diagnosed using an open oral challenge reproducible convincing history positive serum specific immunoglobulin E (sIgE) levels. The sIgE cut-off values were determined by analyzing receiver operating characteristic curves. Out 266 children, 90 (33.8%) confirmed have shrimp allergy. Crab found 37 (39.8%) 93 Of 66 15 (22.7%) be allergic cod. optimal based on largest area under curve 1.43, 3.25, 2.05 kU/L cod, respectively. Levels more than 90% predictive value (PPV) 33.8, 47.5, 29.9 greater negative (NPV) 0.36, 0.04, 3.93 Our results suggest that DDPs levels high PPV NPV can used diagnose