Metabolite Signatures in Hydrophilic Extracts of Mouse Lungs Exposed to Cigarette Smoke Revealed by 1H NMR Metabolomics Investigation

• DOI: 10.4172/2153-0769.1000143
• Publication Date: 2015-07-09T08:30:36Z
• Authors: Hu JZ Wang X
• Keywords: Inosine; Phosphocholine; Inosine monophosphate; Adenosine monophosphate; AMP deaminase

1H-NMR metabolomics was used to investigate the changes of metabolites in lungs mice with and without being exposed a controlled amount cigarette smoke. It found that concentrations adenosine derivatives (i.e. ATP, ADP AMP), inosine uridine were significantly changed smoke when compared controls regardless obese or regular weight. The decreased ADP, AMP elevated suggested deaminases charge conversion would be Indeed, transcriptional study confirmed monophosphate deaminase 2 We also ratio glycerophosphocholine (GPC) phosphocholine (PC) increased those weight mice. GPC/PC further group