Reduction rate of C-reactive protein as an early predictor of postoperative complications and a reliable discharge indicator after gastrectomy for gastric cancer

• DOI: 10.4174/astr.2019.97.2.65
• Publication Date: 2019-07-30T07:54:36Z
• Authors: Si-Hak Lee; Ki Hyun Kim; Cheol Woong Choi; Su Jin Kim; Dae-Hwan Kim; Chang In Choi; Sun-Hwi Hwang
• Keywords: Univariate analysis

Postoperative complications (PCs) after gastrectomy are associated with readmission and longer hospital stay. This study aimed to determine the role of CRP as an early predictor PCs a reliable discharge indicator gastrectomy.Clinicopathologic data 613 patients who underwent for gastric cancer in 2015-2016 were retrospectively analyzed, including consecutive blood samples obtained preoperatively, at operative day, postoperatively. Following Clavien-Dindo classification, divided into group major minor/no PCs. Diagnostic accuracy was determined by area under receiver operating characteristic curve (AUC). Clinical factors related identified using univariate multivariate logistic regression analyses.PCs occurred 89 (14.5%). The most significant predictive factor concentration reduction rate ≤38.1% (AUC, 0.82; sensitivity, 76.4%; specificity, 76.1%) between postoperative day (POD) 3 5 (R5), followed ≤11.1% 0.75; 73%; 76%) POD 2 (R4). When both applied (R4 ≤ 11.1% R5 38.1%), specificity 91.6%; when only one condition satisfied or sensitivity 91%.CRP rates best combination predict indicate safe cancer.