Genetic Markers for Adolescent Idiopathic Scoliosis on Chromosome 19p13.3 among Saudi Arabian Girls

• DOI: 10.4184/asj.2017.11.2.167
• Publication Date: 2017-04-21T08:03:35Z
• Authors: Abdallah Ahmad Al...; Mir Sadat-Ali; Ahmed Sh. Amer; Dakheel A. Al-Dak...
• Keywords: Genetic linkage; Idiopathic scoliosis; Penetrance

<sec><title>Study Design</title><p>Prospective case-controlled study.</p></sec><sec><title>Purpose</title><p>This study aimed to assess genetic influence in Saudi Arabian children with adolescent idiopathic scoliosis (AIS).</p></sec><sec><title>Overview of Literature</title><p>The locus linked chromosome 19p for has been described. A pilot conducted at King Fahd Hospital the University, Al-Khobar showed that three microsatellite markers (D19S216, D19S894, and DS1034) 19p13.3 were significant females compared healthy subjects.</p></sec><sec><title>Methods</title><p>A total 100 unrelated girls treated AIS, their parents, siblings, subjects recruited analysis on 19p13.3. After informed consent was obtained from blood samples collected parametric nonparametric linkage analyses performed using GENEHUNTER ver. 2.1. Multipoint used specify an autosomal dominant trait a gene frequency 0.01 estimated penetrance 80% genotypic allelic levels.</p></sec><sec><title>Results</title><p>Five hundred analyzed Comparison among patients, family members, revealed no association between level: D19S216 (<italic>p</italic>=0.21), D19S894 (<italic>p</italic>=0.37), DS1034 (<italic>p</italic>=0.25). However, level, statistically observed marker (<italic>p</italic>=0.008), significance fathers patients (<italic>p</italic><0.001) mothers. The other two markers, (<italic>p</italic>=0.25) (<italic>p</italic>=0.17), mothers.</p></sec><sec><title>Conclusions</title><p>At significantly associated AIS fathers. This appears be important etiology.</p></sec>