Human papillomavirus in rare unilateral benign intranasal tumours

• DOI: 10.4193/rhin09.010
• Publication Date: 2015-07-28T09:46:44Z
• Authors: S. Kirdar
• Keywords: Malignant Transformation; Inverted Papilloma

Inverted papilloma (IP), oncocytic (OP), respiratory epithelial adenomatoid hamartoma (REAH) and capillary hemangioma (CH) are benign rare tumours. OP IP associated with squamous cell carcinoma (SCC). Human papillomavirus (HPV) may play a role in malignant transformation.We aimed to investigate the presence of HPV, inflammation, dysplasia, prognostic markers including proliferative nuclear antigen (PCNA), epidermal growth fac- tor receptor (EGFR) p53 tissue specimens from unilateral intranasal tumours.Presence HPV DNA was detected by PCR. Proliferative antigen, EGFR, expression type 16 tissues were determined immuno-histochemical analysis.We 2 6 cases, one CH patient patient, but REAH negative. Histologically, only specimen positive for being high risk type. The remaining cases considered as low HPV.Although our numbers limited, there is significant association between HPV. This first study showing cooccurrence