Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs

• DOI: 10.4196/kjpp.2013.17.4.267
• Publication Date: 2013-08-12T01:59:33Z
• Authors: Yu Ji Cho; Chin Ok Yi; Byeong Tak Jeon; Yi Yeong Jeong; Gi Mun Kang; Jung Eun Lee; Gu Seob Roh; Jong Deog Lee
• Keywords: 0303 health sciences; 03 medical and health sciences; Original Article; 3. Good health

A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed investigate whether curcumin, which is known have anti-inflammatory and antioxidant properties, could ameliorate pulmonary inflammation fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior a single irradiation for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage accumulation, interstitial edema, alveolar septal thickness, perivascular fibrosis, collapse radiation-treated lungs inhibited by administration. Radiation-induced transforming growth factor-β1 (TGF-β1), connective tissue factor (CTGF) expression, collagen accumulation also curcumin. Moreover, western blot analysis revealed lowered increases tumor necrosis factor-α (TNF-α), TNF receptor 1 (TNFR1), cyclooxygenase-2 (COX-2). Curcumin nuclear translocation factor-κ B (NF-κB) p65 These results indicate long-term administration may reduce caused radiation treatment.