p-Coumaric Acid Attenuates UVB-Induced Release of Stratifin from Keratinocytes and Indirectly Regulates Matrix Metalloproteinase 1 Release from Fibroblasts

• DOI: 10.4196/kjpp.2015.19.3.241
• Publication Date: 2015-05-06T06:57:59Z
• Authors: Jin Kyung Seok; Yong Chool Boo
• Keywords: Photoaging; HaCaT; MMP1; Human skin

Ultraviolet (UV) radiation-induced loss of dermal extracellular matrix is associated with skin photoaging. Recent studies demonstrated that keratinocyte-releasable stratifin (SFN) plays a critical role in collagen metabolism by inducing metalloproteinase 1 (MMP1) expression target fibroblasts. In the present study, we examined whether SFN released from UVB-irradiated epidermal keratinocytes increases MMP1 release fibroblasts, and these events are affected p-coumaric acid (p-CA), natural phenolic compound UVB-shielding antioxidant properties. HaCaT cells were exposed to UVB absence presence p-CA, conditioned medium was used stimulate fibroblasts transfer experiments. The media analyzed determine expressions/releases MMP1. exposure increased into medium. depletion using siRNA rendered ineffective at stimulating p-CA mitigated UVB-induced keratinocytes, attenuated conclusion, study use UV absorbers such as would reduce UV-induced SFN-centered signaling involved