Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study

• DOI: 10.4196/kjpp.2017.21.6.651
• Publication Date: 2017-11-30T04:27:35Z
• Authors: Hyun Seok Bang; Dae Yun Seo; Young Min Chung; Do Hyung Kim; Sam-Jun Lee; Sung Ryul Lee; Hyo-Bum Kwak; Tae Nyun Kim; Min Kim; Kyoung-Mo Oh; Young Jin Son; Sanghyun Kim; Jin Han
• Keywords: Creatine kinase; Ursolic acid; Leg press

Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed determine, using the same experimental paradigm, whether UA also has beneficial effects on exercise-induced damage markers including levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) Sixteen healthy participants were randomly assigned resistance training (RT) or RT+UA groups (n=8 per group). Participants trained according RT program (60~80% 1 repetition, 6 times/week), group additionally given (450 mg/day) for 8 weeks. Blood samples obtained before after intervention, BNP, CK, CK-MB, LDH analyzed. Subjects who underwent alone showed no significant change body composition damage, whereas slightly decreased weight fat percentage increased lean mass, but without statistical significance. In addition, significantly (p<0.05). conclusion, alleviates RT. finding provides evidence a potential new therapy