Maternal separation in mice leads to anxiety-like/aggressive behavior and increases immunoreactivity for glutamic acid decarboxylase and parvalbumin in the adolescence ventral hippocampus

• DOI: 10.4196/kjpp.2023.27.1.113
• Publication Date: 2022-12-28T08:23:43Z
• Authors: Eu-Gene Kim; Wonseok Chang; SangYep Shin; Anjana Silwal Adh...; Geun Hee Seol; Dae-Yong Song; Sun Seek Min
• Keywords: Subiculum; Elevated plus maze; Corticosterone; Cytoarchitecture

It has been reported that stressful events in early life influence behavior adulthood and are associated with different psychiatric disorders, such as major depression, post-traumatic stress disorder, bipolar anxiety disorder. Maternal separation (MS) is a representative animal model for reproducing childhood stress. used an well-known effects, increasing causing abnormalities the hypothalamic-pituitary-adrenal (HPA) axis. This study investigated effect of MS on or aggression-like number GABAergic neurons hippocampus. Mice were separated from their dams four hours per day 19 d postnatal two. Elevated plus maze (EPM) test, resident-intruder (RI) counted glutamic acid decarboxylase 67 (GAD67) parvalbumin (PV) positive cells hippocampus executed using immunohistochemistry. The maternal segregation group exhibited increased aggression EPM test RI test. GAD67-positive hippocampal regions we observed: dentate gyrus (DG), CA3, CA1, subiculum, presubiculum, parasubiculum. PV-positive DG, Consistent behavioral changes, corticosterone was group, suggesting changes induced by expressed through HPA Altogether, alters levels, possibly alteration cytoarchitecture output ventral induces dysfunction