Antidepressant and cognitive activities of intranasal piperine-encapsulated liposomes

• DOI: 10.4236/abb.2011.22017
• Publication Date: 2011-05-03T05:03:19Z
• Authors: Aroonsri Priprem; Pennapa Chonpatho...; Saengrawee Sutthi...; Jintanaporn Watta...
• Keywords: Piperine

Antidepressant and cognitive effects of piperine -encapsulated liposomes (PL) were investigated in male Wistar rats. Oral (5 mg/kg body weight/day) intranasal PL (7.2 µg/day) randomly assigned to daily administer for 14 days rats which subjected forced swimming, Mor-ris water maze spontaneous motor behavior tests. significantly exhibited anti-depression like activity enhancing effects, comparison the control groups after first dose (p < 0.01) could be maintained throughout period study. Quantitative analysis brain homogenates by HPLC indicated that piperine, delivered either orally or nasally, distributed hippocampus at a higher extent than cortex time peak concentration nasal was shorter oral piperine. Intranasal was, thus, potential delivery low dose, exert its an-tidepressant activities.