Association between IL-1β, IL-8, and IL-10 polymorphisms and risk of acute pancreatitis

• DOI: 10.4238/2015.june.18.6
• Publication Date: 2015-06-18T20:28:33Z
• Authors: D. Li; J. Li; L. Wang; Q. Zhang
• Keywords: Adult; Male; 0301 basic medicine; Genotype; Pancreatitis, Acute Necrotizing; Interleukin-1beta; Interleukin-8; Middle Aged; Polymorphism, Single Nucleotide; Interleukin-10; 3. Good health; 03 medical and health sciences; Risk Factors; Humans; Female; Genetic Predisposition to Disease; Alleles; Genetic Association Studies; Aged

We assessed the possible correlation between genetic polymorphisms in interleukin (IL)-1β, IL-8, and IL-10 and risk of acute pancreatitis. Polymorphisms of IL-1β+3954C/T (rs1143634), IL-1β-511C/T (rs16944), IL-8 -251T/A (rs4073), IL-10 -1082A/G (rs1800896), and IL-10 -819C/T (rs1800871) were assessed by polymerase chain reaction-restriction fragment length polymorphism. Patients with acute pancreatitis were more likely to have a family history of acute pancreatitis and a habit of tobacco smoking and alcohol drinking. Conditional logistic regression analyses showed that subjects carrying IL-10 -1082A/G and IL-8 -251 AA genotype with the A allele were significantly associated with an increased risk of acute pancreatitis, with adjusted odds ratio (95% confidence interval) of 1.82 (1.01-3.31) and 1.39 (1.02-1.90), respectively. However, we did not observe that IL-1β +3954C/T, IL-1β -511C/T, IL-10 -1082A/G, and IL-10 -819C/T polymorphisms were associated with the risk of acute pancreatitis. We found that the IL-8 -251T/A polymorphism is associated with an increased risk of acute pancreatitis, and no significant association between IL-1βand IL-10 gene polymorphisms and risk of acute pancreatitis was detected.