Investigation of AZF microdeletions in patients with Klinefelter syndrome

• DOI: 10.4238/2015.november.25.2
• Publication Date: 2015-12-04T11:36:15Z
• Authors: L.X. Li; H.Y. Dai; X.P. Ding; Y.P. Zhang; X.H. Zhang; H.Y. Ren; Z.Y. Chen
• Keywords: Azoospermia factor; Y chromosome microdeletion; Klinefelter syndrome

We investigated azoospermia region microdeletions in male infertility patients with Klinefelter syndrome (KFS), as well the association between symptoms KFS and Y chromosome microdeletion polymorphisms.A total of 111 cases confirmed to have (47, XXY) 94 fertile men were included this study.Peripheral blood was drawn DNA extracted from these samples.Multiplex polymerase chain reaction performed screen partial deletions 25 sequence-tagged sites on chromosome.In KFS, 1 case contained AZFb+d+c deletion.The Gr/Gr deletion identified 12 5 control cases.In addition, b2/b3 13 6 cases.There no significant differences phenotype genotype 2 AZFc controls (P > 0.05).Our results suggest that may also varying degrees ©FUNPEC-RP www.funpecrp.com.brGenetics Molecular Research 14 (4): 15140-15147 (2015) gr/gr not play a role susceptible genetic background Sichuan population.