Association of interleukin gene polymorphisms with the risk of coronary artery disease

• DOI: 10.4238/2015.october.16.16
• Publication Date: 2015-10-20T20:24:48Z
• Authors: H.T. Yang; S.L. Wang; L.J. Yan; P. Qian; H.Y. Duan
• Keywords: Adult; Aged, 80 and over; Male; 0303 health sciences; Interleukin-6; Interleukins; Interleukin-1beta; Interleukin-8; Genetic Variation; Coronary Artery Disease; Middle Aged; Interleukin-10; 3. Good health; 03 medical and health sciences; Gene Frequency; Case-Control Studies; Humans; Female; Genetic Predisposition to Disease; Alleles; Genetic Association Studies; Polymorphism, Restriction Fragment Length; Aged

We conducted a case-control study to investigate the genetic variants Interleukin-1β(IL-1β) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) -819C/T (rs1800871) in development of coronary artery disease (CAD). A total 410 individuals with CAD were enrolled between January 2012 December 2014. Genotyping five gene polymorphisms was performed using polymerase chain reaction combined restriction fragment length polymorphism methodology. By multivariate logistic regression analysis, we found that frequencies CC genotype C allele significantly correlated higher risk CAD; adjusted ORs (95%CIs) 2.37 (1.37-4.14) 1.49 (1.19-1.86), respectively. In addition, AG GG genotypes G also associated CAD, 1.42 (1.04-1.95), 2.16 (1.42-3.30), 1.56 (1.27-1.93), However, IL-1β+3953 C/T, -251T/A, did not correlate risk. Our suggests (rs1800795) might be involved pathogenesis likely contribute susceptibility for CAD.