Human colorectal cancer cells frequently express IgG and display unique Ig repertoire

• DOI: 10.4251/wjgo.v11.i3.195
• Publication Date: 2019-03-15T05:55:26Z
• Authors: Zi-Han Geng; Chun-Xiang Ye; Yan Huang; Hong-Peng Jiang; Ying-Jiang Ye; Shan Wang; Yuan Zhou; Zhan-Long Shen; Xiao-Yan Qiu
• Keywords: 0303 health sciences; 03 medical and health sciences; Basic Study; 3. Good health

BACKGROUNDThere is growing evidence proving that many human carcinomas, including colon cancer, can overexpress immunoglobulin (Ig); the non B cancer cell-derived Ig usually displayed unique V(D)J rearrangement pattern are distinct from Ig.Especially, cancer-derived plays important roles in initiation, progression, and metastasis.However, it still remains unclear if display sequencing, which be used as novel target for therapy. AIMTo investigate repertoire features expressed cells.