MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling

• DOI: 10.4251/wjgo.v14.i11.2170
• Publication Date: 2022-11-14T05:50:16Z
• Authors: Xiao-Jing Gu; Ya-Jun Li; Fang Wang; Ting Ye
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; Basic Study; 3. Good health

Gastric cancer (GC) is a common type of digestive with high morbidity and mortality rates worldwide. Considerable effort has been expended in understanding the mechanism GC development metastasis. The current study therefore explores involvement microRNAs regulation progression.To explore expression function miR-30e-3p development.MiR-30e-3p was found to be downregulated GC, low levels thereof predicting poor outcomes among patients GC. Functionally, we revealed that suppressed cell growth metastatic behaviors cells. Bioinformatics analysis predicted THO complex 2 (THOC2) direct target miR-30e-3p, interaction between THOC2 further validated by luciferase reporter assay.Our findings knockdown inhibited After investigating signaling pathways involved regulation, miR-30e-3p/THOC2 axis regulated PI3K/AKT/mTOR pathway GC.Our suggest novel functional progression. could utilized develop new therapies against